|
Symbol Name ID |
Tgfbr2
transforming growth factor, beta receptor II MGI:98729 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukemia |
Lymphadenopathy |
Hepatosplenomegaly |
Eosinophilic infiltration of the esophagus |
Peritoneal abscess |
| Disease(s) Associated with TGFBR2 | |||||
| Loeys-Dietz syndrome 2 | |||||
| mismatch repair cancer syndrome | |||||
| pancreatic cancer |
| Mouse Phenotypes | immune system phenotype |
increased T cell proliferation |
stomach inflammation |
small thymus |
pancreas inflammation |
enlarged spleen |
decreased Langerhans cell number |
absent plasma cells |
increased memory T cell number |
increased regulatory T cell number |
increased leukocyte cell number |
abnormal B-1 B cell morphology |
abnormal B-1 B cell number |
abnormal CD8-positive, alpha beta T cell morphology |
microgliosis |
abnormal B cell physiology |
decreased IgA level |
increased IgG level |
increased IgM level |
abnormal T cell activation |
enlarged Peyer's patches |
enlarged lymph nodes |
autoimmune response |
increased inflammatory response |
eye inflammation |
liver inflammation |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Tg(CD2-Tgfbr2)1Grs/0 | |||||||||||||||||||||||||||
| Tg(CD2-Tgfbr2)1Grs/? | |||||||||||||||||||||||||||
| Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(CD207-cre)1Dhka/? (conditional) |
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| Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Tg(Cd4-cre)1Cwi/0 (conditional) |
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| Tg(CAG-cre/Esr1*)5Amc/0 Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm (conditional) |
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| Tgfbr2tm1Karl/Tgfbr2tm1Karl Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Tgfbr2tm1Karl/Tgfbr2tm1Karl H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Cd4tm1(cre/ERT2)Thbu/Cd4+ Tgfbr2tm1Karl/Tgfbr2tm1Karl (conditional) |
* | ||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Tgfbr2tm1Roes/Tgfbr2tm1Roes (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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